The Fortunes of Ferdinand Flipper #[nn]

The first comic book created solely in the United States and not reprinted from elsewhere.

New York. Published at the Brother Jonathan office. Printed by C. A. Alvord. Digital copy: http://collections.dartmouth.edu/published-derivatives/ocm28211308/pdf/ocm28211308.pdf

An article in the New-York Tribune, dated March 26, 1851, on page 1, lists new book releases with the earliest known mention of this book, therefore making the approximate release date March 1851. It also mentioned it was being sold for 25 cents (https://www.newspapers.com/article/new-york-tribune-new-publications/178124470/).